| 2006 | Acceptable in the 80s | Calvin Harris | 5 | 5 |
| 2007 | Rock Band | Calvin Harris | | 1 |
| 2007 | The Girls | Calvin Harris | | 2 |
| 2007 | Merrymaking at My Place | Calvin Harris | | 6 |
| 2007 | Colours | Calvin Harris | | 3 |
| 2008 | Dance Wiv Me | Dizzee Rascal feat. Calvin Harris & Chrome | | 9 |
| 2009 | Dance Wiv Me (Special Version) | Dizzee Rascal featuring Calvin Harris and Chromeo | | 1 |
| 2009 | I’m Not Alone | Calvin Harris | | 9 |
| 2009 | I'm Not Alone (Radio Edit) | Calvin Harris | | 1 |
| 2009 | Ready for the Weekend | Calvin Harris | | 4 |
| 2009 | Flashback | Calvin Harris | | 3 |
| 2010 | You Used to Hold Me | Calvin Harris | | 1 |
| 2011 | Bounce | Calvin Harris feat. Kelis | | 7 |
| 2011 | Feel So Close | Calvin Harris | | 4 |
| 2011 | We Found Love | Rihanna feat. Calvin Harris | 4.5 | 3 |
| 2012 | Let's Go (feat. Ne-Yo) [Radio Edit] | Calvin Harris | | 1 |
| 2012 | Sweet Nothing | Calvin Harris feat. Florence Welch | | 6 |
| 2012 | Let’s Go | Calvin Harris feat. Ne‐Yo | 3.5 | 2 |
| 2012 | We'll Be Coming Back | Calvin Harris feat. Example | | 1 |
| 2012 | Iron | Nicky Romero & Calvin Harris | | 1 |
| 2013 | I Need Your Love | Calvin Harris feat. Ellie Goulding | | 5 |
| 2013 | Thinking About You | Calvin Harris | | 1 |
| 2013 | Under Control | Calvin Harris & Alesso feat. Hurts | | 4 |
| 2014 | Outside | Calvin Harris feat. Ellie Goulding | | 5 |
| 2014 | Summer | Calvin Harris | | 2 |
| 2014 | C.U.B.A | Calvin Harris | | 1 |
| 2014 | Blame | Calvin Harris feat. John Newman | | 3 |
| 2014 | Open Wide | Calvin Harris feat. Big Sean | | 1 |
| 2014 | Burnin' | Calvin Harris & R3HAB | | 1 |
| 2015 | Overdrive (Pt. 2) | Calvin Harris & Ummet Ozcan | | 1 |
| 2015 | Pray to God | Calvin Harris feat. HAIM | | 5 |
| 2015 | How Deep Is Your Love | Calvin Harris + Disciples | | 2 |
| 2016 | This Is What You Came For | Calvin Harris feat. Rihanna | 4 | 1 |
| 2016 | Hype | Dizzee Rascal & Calvin Harris | | 1 |
| 2016 | My Way | Calvin Harris | | 2 |
| 2017 | Slide | Calvin Harris feat. Frank Ocean & Migos | | 2 |
| 2017 | Slide (feat. Frank Ocean & Migos) | Calvin Harris | | 1 |
| 2017 | Heatstroke | Calvin Harris ft. Young Thug, Pharrell Williams & Ariana Grande | 5 | 3 |
| 2017 | Rollin | Calvin Harris feat. Future & Khalid | | 1 |
| 2017 | Feels | Calvin Harris feat. Pharrell Williams, Katy Perry & Big Sean | | 3 |
| 2017 | Faking It | Calvin Harris feat. Kehlani & Lil Yachty | | 1 |
| 2017 | Get Up | Alan Walker, Calvin Harris & Ed Sheeran | | 1 |
| 2018 | Nuh Ready Nuh Ready | Calvin Harris feat. PARTYNEXTDOOR | | 2 |
| 2018 | Nuh Ready Nuh Ready (feat. PARTYNEXTDOOR) | Calvin Harris | | 1 |
| 2018 | One Kiss | Calvin Harris & Dua Lipa | 4.5 | 3 |
| 2018 | Promises | Calvin Harris & Sam Smith | | 3 |
| 2018 | I Found You | benny blanco & Calvin Harris | | 1 |
| 2019 | I Found You / Nilda’s Story | benny blanco, Calvin Harris & Miguel | | 2 |
| 2019 | Giant | Calvin Harris & Rag’n’Bone Man | | 2 |
| 2020 | Over Now | Calvin Harris & The Weeknd | 5 | 2 |
| 2021 | By Your Side | Calvin Harris feat. Tom Grennan | | 2 |
| 2022 | Potion | Calvin Harris, Dua Lipa & Young Thug | | 4 |
| 2022 | New Money | Calvin Harris & 21 Savage | | 1 |
| 2022 | Stay With Me | Calvin Harris, Justin Timberlake, Halsey & Pharrell | | 3 |
| 2022 | New to You | Calvin Harris, Normani, Tinashe & Offset | | 3 |
| 2023 | Miracle | Calvin Harris & Ellie Goulding | | 16 |
| 2023 | Desire | Calvin Harris & Sam Smith | | 7 |
| 2023 | Body Moving | Eliza Rose starring Calvin Harris | | 3 |
| 2024 | Lovers in a Past Life | Calvin Harris with Rag’n’Bone Man | | 6 |
| 2024 | Free | Calvin Harris with Ellie Goulding | | 9 |
| 2025 | SMOKE THE PAIN AWAY | Calvin Harris | | 2 |
| 2025 | Faded Into US | Syed Fardeen, David Guetta & Calvin Harris | | 1 |
| 2025 | Blessings | Calvin Harris feat. Clementine Douglas | | 5 |
| 2025 | I’m Not Alone (Oliver Heldens & Centre Court remix) | Calvin Harris | | 3 |
| 2025 | Sweet Nothing (2025 edit) | D.O.D & Calvin Harris feat. Florence Welch | | 2 |
| 2025 | Ocean | Calvin Harris & Jessie Reyez | | 2 |
| 2026 | Release the Pressure | Calvin Harris & Kasabian | | 2 |
| 2026 | Satisfy | Calvin Harris * Jazzy | | 2 |
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